| Identification | Back Directory | [Name]
ADINAZOLAM | [CAS]
37115-32-5 | [Synonyms]
U-41123
ADINAZOLAM
Adinazolamum
Adinazolam (CRM)
8-Chloro-N,N-dimethyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-1-methanamine
4H-[1,2,4]Triazolo[4,3-a][1,4]benzodiazepine-1-methanamine, 8-chloro-N,N-dimethyl-6-phenyl-
γ-Aminobutyric acid Receptor,sickness,antihistamine,GABA Receptor,inhibit,Adinazolam,U-41123,U 41123,Huntington,Gamma-aminobutyric acid Receptor,anti-motion,piperazine,U41123,Inhibitor | [Molecular Formula]
C19H18ClN5 | [MDL Number]
MFCD00865341 | [MOL File]
37115-32-5.mol | [Molecular Weight]
351.83 |
| Chemical Properties | Back Directory | [Melting point ]
171-172.5° (US 4250094); mp 165-166° (DE 2201210) | [Boiling point ]
527.0±60.0 °C(Predicted) | [density ]
1.31±0.1 g/cm3(Predicted) | [storage temp. ]
-10 to -25°C | [form ]
Solid | [pka]
pKa 6.2 (D2O/DClor D2O/NaOD ) (Uncertain);5.8±0.1(D2O/DClor D2O/NaOD ) (Uncertain) | [color ]
White to off-white | [InChI]
1S/C19H18ClN5/c1-24(2)12-18-23-22-17-11-21-19(13-6-4-3-5-7-13)15-10-14(20)8-9-16(15)25(17)18/h3-10H,11-12H2,1-2H3 | [InChIKey]
GJSLOMWRLALDCT-UHFFFAOYSA-N | [SMILES]
Clc1cc2c(cc1)[n]3c(nnc3CN(C)C)CN=C2c4ccccc4 |
| Hazard Information | Back Directory | [Uses]
Antidepressant; sedative-hypnotic. | [Definition]
ChEBI: A triazolo[4,3-a][1,4]benzodiazepine having a dimethylaminomethyl group at the 1-position, a phenyl group at the 6-position and a chloro substituent at the 8-position. | [in vivo]
Adinazolam (6 mg/kg) increases shuttlebox avoidance acquisition in male Sprague-Dawley rats[2]. | Animal Model: | Male Sprague-Dawley rats weighing 409±30 g[2] | | Dosage: | 6 mg/kg | | Administration: | Administered i.p. in 2 mL/kg | | Result: | Increased avoidance acquisition in 195% as compared to control animals.
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