| Identification | Back Directory | [Name]
ethyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate | [CAS]
37178-37-3 | [Synonyms]
TV-1203
L-Dopa-Et
O-Ethyl-DOPA
L-DOPA Ethyl Ester
Levodopa ethyl ester
L-Dopa ethyl ester >=98% (HPLC)
3-Hydroxy-L-tyrosine ethyl ester
L-Tyrosine, 3-hydroxy-, ethyl ester
3,4-Dihydroxy-L-phenylalanine ethyl ester
ethyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate
2(S)-Amino-3-(3,4-dihydroxyphenyl)propionic acid ethyl ester | [Molecular Formula]
C11H15NO4 | [MDL Number]
MFCD00871210 | [MOL File]
37178-37-3.mol | [Molecular Weight]
225.24 |
| Chemical Properties | Back Directory | [Boiling point ]
394.2±37.0 °C(Predicted) | [density ]
1.278±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
H2O: ≥12mg/mL at warmed to 60°C | [form ]
powder | [pka]
9.67±0.20(Predicted) | [color ]
white to tan | [Optical Rotation]
[α]/D +15 to +19°, c =1 in methanol ([α]/D) | [Water Solubility ]
H2O: ≥12mg/mL atwarmed to 60°C | [InChI]
1S/C11H15NO4/c1-2-16-11(15)8(12)5-7-3-4-9(13)10(14)6-7/h3-4,6,8,13-14H,2,5,12H2,1H3/t8-/m0/s1 | [InChIKey]
NULMGOSOSZBEQL-QMMMGPOBSA-N | [SMILES]
CCOC(=O)[C@@H](N)Cc1ccc(O)c(O)c1 |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
22-36 | [Safety Statements ]
26 | [WGK Germany ]
3 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral
Eye Irrit. 2 |
| Hazard Information | Back Directory | [Uses]
Antiparkisonian. | [Definition]
ChEBI: Etilevodopa is a tyrosine derivative. | [Biochem/physiol Actions]
L-Dopa ethyl ester is a prodrug of levodopa that has greater gastric solubility. The drug is rapidly hydrolyzed to levodopa by nonspecific esterases in the gastrointestinal tract. L-Dopa ethyl ester (etilevodopa)-carbidopa treatment was well tolerated but did not demonstrate better efficacy compared with standard levodopa-carbidopa treatment. L-Dopa ethyl ester should have a significant brain penetration following an administration by injection. |
|
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|