| Identification | Back Directory | [Name]
(5R,7R)-rel-7-[[4-(2,6-Dichlorophenyl)-1-piperidinyl]methyl]-6,7,8,9-tetrahydro-1-methyl-5H-benzocyclohepten-5-ol hydrochloride | [CAS]
371980-94-8 | [Synonyms]
SB 61211 hydrochloride
rel-SB-612111 hydrochloride
relSB612111 hydrochloride,rel SB 612111 hydrochloride
(5R,7R)-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl]-1-methyl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-ol
(5S,7S)-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl]-1-methyl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-ol
(5S,7S)-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl]-1-methyl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-ol:hydrochloride
(5R,7R)-rel-7-[[4-(2,6-Dichlorophenyl)-1-piperidinyl]methyl]-6,7,8,9-tetrahydro-1-methyl-5H-benzocyclohepten-5-ol hydrochloride
rel-(5R,7R)-7-[[4-(2,6-Dichlorophenyl)-1-piperidinyl]methyl]-6,7,8,9-tetrahydro-1-methyl-5H-benzocyclohepten-5-ol Hydrochloride | [Molecular Formula]
C24H30Cl3NO | [MOL File]
371980-94-8.mol | [Molecular Weight]
454.86 |
| Hazard Information | Back Directory | [Uses]
SB 612111 Hydrochloride is used in the synthetic preparation of benzosuberonylpiperidines as analgesics. | [in vivo]
rel-SB-612111 hydrochloride (intravenous?injection; 0.6-10 nmol/mouse) antagonize nociceptin-induced thermal hyperalgesia in a dose-dependent manner with an ED50 of 0.62 mg/kg[1].
rel-SB-612111 hydrochloride (intravenous?injection; 0.1-5 mg/kg) causes a significant inhibition of the carrageenan-induced reduction in paw withdrawal latencies in rat, however, untreated paw are uneffected[1]. | Animal Model: | Male rats[1] | | Dosage: | 0.1 mg/kg, 0.3 mg/kg, 1 mg/kg, 3 mg/kg, 5 mg/kg | | Administration: | Intravenous?injection; single dose | | Result: | Had antihyperalgesic effects on carrageenan-induced rat paw. |
| [IC 50]
NOP Receptor/ORL1 | [storage]
Store at -20°C |
|
| Company Name: |
BOC Sciences
|
| Tel: |
|
| Website: |
https://www.bocsci.com |
| Company Name: |
Carbosynth
|
| Tel: |
+86 512 6260 5585 |
| Website: |
www.carbosynth.com |
|