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Convulxin is a toxin that was first isolated from rattlesnake venom. It activates the collagen receptor glycoprotein VI (GPVI) on platelets and initiates blood clotting. Convulxin is used to study signaling through GPVI and to characterize platelet function. | [References]
[1] BERNARD B. VARGAFTING. Activation of guinea-pig platelets induced by convulxin, a substance extracted from the venom of Crotalus durissus cascavella[J]. European journal of pharmacology, 1980, 68 4: Pages 451-464. DOI: 10.1016/0014-2999(80)90420-3
[2] M JANDROT-PERRUS. Adhesion and activation of human platelets induced by convulxin involve glycoprotein VI and integrin alpha2beta1.[J]. The Journal of Biological Chemistry, 1997, 272 43: 27035-27041. DOI: 10.1074/jbc.272.43.27035
[3] MANASH S CHATTERJEE. Systems biology of coagulation initiation: kinetics of thrombin generation in resting and activated human blood.[J]. PLoS Computational Biology, 2010. DOI: 10.1371/journal.pcbi.1000950
[4] CATERINA CASARI. von Willebrand factor mutation promotes thrombocytopathy by inhibiting integrin αIIbβ3.[J]. Journal of Clinical Investigation, 2013, 123 12: 5071-5081. DOI: 10.1172/jci69458
[5] ESTHER R VAN BLADEL. Functional platelet defects in children with severe chronic ITP as tested with 2 novel assays applicable for low platelet counts.[J]. Blood, 2014, 123 10: 1556-1563. DOI: 10.1182/blood-2013-08-519686 |
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