| Identification | Back Directory | [Name]
4-(8-(piperazin-1-yl)-1,2,3,4-tetrahydro-[1,2,3]triazino[4',5':4,5]thieno[2,3-c]isoquinolin-5-yl)morpholine | [CAS]
372495-52-8 | [Synonyms]
UNC10201652
4-(8-(piperazin-1-yl)-1,2,3,4-tetrahydro-[1,2,3]triazino[4',5':4,5]thieno[2,3-c]isoquinolin-5-yl)morpholine
[1,2,3]Triazino[4',5':4,5]thieno[2,3-c]isoquinoline, 1,2,3,4-tetrahydro-5-(4-morpholinyl)-8-(1-piperazinyl)- | [Molecular Formula]
C20H25N7OS | [MOL File]
372495-52-8.mol | [Molecular Weight]
411.524 |
| Chemical Properties | Back Directory | [Boiling point ]
723.7±70.0 °C(Predicted) | [density ]
1.378±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 2mg/mL, clear | [form ]
Solid | [pka]
8.01±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
UNC10201652 is a potent Loop 1 (L1)-specific gut bacterial β-glucuronidase (GUSs) inhibitor with an IC50 value of 0.117 μM for E. coli GUS. UNC10201652 can block SN-38 glucuronide.html" class="link-product" target="_blank">SN-38 glucuronide (HY-126373) processing only in individuals whose fecal gut microbiota is highly abundant in L1 GUS enzymes[1][2]. | [References]
[1] Jariwala PB, et al. Discovering the Microbial Enzymes Driving Drug Toxicity with Activity-Based Protein Profiling. ACS Chem Biol. 2020 Jan 17;15(1):217-225. DOI:10.1021/acschembio.9b00788
[2] Pellock SJ, et al. Gut Microbial β-Glucuronidase Inhibition via Catalytic Cycle Interception. ACS Cent Sci. 2018 Jul 25;4(7):868-879. DOI:10.1021/acscentsci.8b00239 |
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| Company Name: |
Merck KGaA
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21-20338288 |
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www.sigmaaldrich.cn |
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