| Identification | Back Directory | [Name]
factor 420 | [CAS]
37333-48-5 | [Synonyms]
factor 420
Coenzyme FO
7,8-didemethyl-8-hydroxy-5-deazariboflavin | [Molecular Formula]
C16H17N3O7 | [MDL Number]
MFCD32874120 | [MOL File]
37333-48-5.mol | [Molecular Weight]
363.322 |
| Hazard Information | Back Directory | [Uses]
Coenzyme FO, a deazaflavin chromophore, acts as an important hydride acceptor/donor in the central methanogenic pathway[1][2]. | [Definition]
ChEBI: Riboflavin in which the nitrogen at position 5 is replaced by CH and the methyl groups at positions 7 and 8 are substituted by hydrogen and hydroxy, respectively. | [storage]
Store at -20°C | [References]
[1] Mills DJ, et al. De novo modeling of the F(420)-reducing [NiFe]-hydrogenase from a methanogenic archaeon by cryo-electron microscopy. Elife. 2013;2:e00218. Published 2013 Mar 5. DOI:10.7554/eLife.00218
[2] Philmus B, et al. Biosynthetic versatility and coordinated action of 5'-deoxyadenosyl radicals in deazaflavin biosynthesis. J Am Chem Soc. 2015;137(16):5406-5413. DOI:10.1021/ja513287k
[3] de Poorter LMI, et al. Hydrogen concentrations in methane-forming cells probed by the ratios of reduced and oxidized coenzyme F420. Microbiology. 2005;151(Pt 5):1697‐1705. DOI:10.1099/mic.0.27679-0
[4] Purwantini E, et al. Conversion of NO2 to NO by reduced coenzyme F420 protects mycobacteria from nitrosative damage. Proc Natl Acad Sci U S A. 2009;106(15):6333‐6338. DOI:10.1073/pnas.0812883106 |
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