| Identification | Back Directory | [Name]
PMPA sodium salt | [CAS]
373645-42-2 | [Synonyms]
PMPA sodium salt
2-PMPA tetrasodium
PMPA tetrasodium/PMPA sodium salt | [Molecular Formula]
C6H12NaO7P | [MDL Number]
MFCD01862672 | [MOL File]
373645-42-2.mol | [Molecular Weight]
250.12 |
| Hazard Information | Back Directory | [Uses]
2-PMPA sodium is a potent and selective inhibitor of glutamate carboxypeptidase II (GCPII) with an IC50 of 300 pM. | [storage]
Store at -20°C | [References]
[1] Rais R, et al. Bioanalytical method for evaluating the pharmacokinetics of the GCP-II inhibitor 2-phosphonomethyl pentanedioic acid (2-PMPA). J Pharm Biomed Anal. 2014 Jan;88:162-9. DOI:10.1016/j.jpba.2013.08.028
[2] Zuo D, et al. Existence of glia mitigated ketamine-induced neurotoxicity in neuron-glia mixed cultures of neonatal rat cortex and the glia-mediated protective effect of 2-PMPA. Neurotoxicology. 2014 Sep;44:218-30. DOI:10.1016/j.neuro.2014.06.002
[3] Baslow MH, et al. 2-PMPA, a NAAG peptidase inhibitor, attenuates magnetic resonance BOLD signals in brain of anesthetized mice: evidence of a link between neuron NAAG release and hyperemia. J Mol Neurosci. 2005;26(1):1-15. DOI:10.1385/JMN:26:1:001
[4] Nagel J, et al. Effects of NAAG peptidase inhibitor 2-PMPA in model chronic pain-relation to brain concentration. Neuropharmacology. 2006 Dec;51(7-8):1163-71. DOI:10.1016/j.neuropharm.2006.07.018 |
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