| Identification | Back Directory | [Name]
PYRROLIDIN-1-YL-ACETIC ACID | [CAS]
37386-15-5 | [Synonyms]
AKOS BC-0363
AKOS BBS-00000323
RARECHEM AL BO 0350
SALOR-INT L481092-1EA
N-PYRROLIDINOACETIC ACID
1-PYRROLIDINEACETIC ACID
1-PYRROLIDINYLACETIC ACID
1-Pyrroltdinylacetic acid
Pyrroldin-1-yl-acetic acid
PYRROLIDIN-1-YL-ACETIC ACID
2-(1-Pyrrolidyl)acetic Acid
pyrrolidin-1-ylacetic acid(SALTDATA: FREE)
1-Pyrrolidinylacetic acid
N-Pyrrolidinoacetic acid | [Molecular Formula]
C6H11NO2 | [MDL Number]
MFCD04114075 | [MOL File]
37386-15-5.mol | [Molecular Weight]
129.16 |
| Chemical Properties | Back Directory | [Melting point ]
184-185 °C | [Boiling point ]
233.8±23.0 °C(Predicted) | [density ]
1.153±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
DMSO (Slightly, Sonicated, Heated), Methanol (Slightly) | [form ]
Solid | [pka]
2.47±0.10(Predicted) | [color ]
Pale Yellow | [InChI]
InChI=1S/C6H11NO2/c8-6(9)5-7-3-1-2-4-7/h1-5H2,(H,8,9) | [InChIKey]
IPXNXMNCBXHYLQ-UHFFFAOYSA-N | [SMILES]
N1(CC(O)=O)CCCC1 |
| Hazard Information | Back Directory | [Uses]
1-?Pyrrolidineacetic Acid is a useful reactant and reagent in organic reactions. It can be found used in cosmetic products such as wrinkle-?preventive?/ameliorating products. | [Synthesis]
b) Synthesis of 2-(pyrrolidin-1-yl)acetic acid: ethyl 2-(pyrrolidin-1-yl)acetate (2 g, 12.7 mmol, 1.0 eq.) was dissolved in 8N HCl and the reaction was stirred for 16 hrs. at 95°C. Upon completion of the reaction, the mixture was concentrated, the reaction was quenched and extracted as in Intermediate Example 15(b). Subsequently, the solvent was removed by distillation to afford the target product 2-(pyrrolidin-1-yl)acetic acid in 91% (1.5 g) yield. The product was analyzed by LC-MS (ESI): calculated mass 129.1; measured mass 130.1 [M + H]+ (retention time: 0.26 min). | [References]
[1] Patent: WO2013/53983, 2013, A1. Location in patent: Page/Page column 40
[2] Patent: US2015/11548, 2015, A1. Location in patent: Paragraph 0161
[3] Liebigs Annalen der Chemie, 1983, # 6, p. 950 - 961 |
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