374913-63-0

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374913-63-0 Structure

Identification	Back Directory
[Name] Madrasin
[CAS] 374913-63-0
[Synonyms] CS-2251 Madrasin DD00107587 DDD00107587 DDD-00107587 Madrasin >=98% (HPLC) DDD00107587;DD00107587;DDD-00107587 4(3H)-Pyrimidinone, 2-[(7-methoxy-4-methyl-2-quinazolinyl)amino]-5,6-dimethyl-
[Molecular Formula] C16H17N5O2
[MDL Number] MFCD02233199
[MOL File] 374913-63-0.mol
[Molecular Weight] 311.34

Chemical Properties	Back Directory
[storage temp. ] 2-8°C
[solubility ] DMSO:1.5(Max Conc. mg/mL);4.82(Max Conc. mM)
[form ] powder
[color ] white to dark brown

Safety Data	Back Directory
[Symbol(GHS) ] GHS07
[Signal word ] Warning
[Hazard statements ] H302
[Precautionary statements ] P301+P312+P330

Hazard Information	Back Directory
[Uses] Madrasin has been used as a spliceosome inhibitor to inhibit pre-mRNA processing in 3T3-L1 cells.
[Definition] ChEBI: 2-[(7-methoxy-4-methyl-2-quinazolinyl)amino]-5,6-dimethyl-1H-pyrimidin-4-one is a member of quinazolines.
[Biochem/physiol Actions] Madrasin is a potent and cell penetrant splicing inhibitor that interferes with the early stages of spliceosome assembly. Madrasin stalls spliceosome assembly at the A complex.
[storage] Store at -20°C

Spectrum Detail	Back Directory
[Spectrum Detail] Madrasin(374913-63-0)¹HNMR

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