| Identification | Back Directory | [Name]
Madrasin | [CAS]
374913-63-0 | [Synonyms]
CS-2251
Madrasin
DD00107587
DDD00107587
DDD-00107587
Madrasin >=98% (HPLC)
DDD00107587;DD00107587;DDD-00107587
4(3H)-Pyrimidinone, 2-[(7-methoxy-4-methyl-2-quinazolinyl)amino]-5,6-dimethyl- | [Molecular Formula]
C16H17N5O2 | [MDL Number]
MFCD02233199 | [MOL File]
374913-63-0.mol | [Molecular Weight]
311.34 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
DMSO:1.5(Max Conc. mg/mL);4.82(Max Conc. mM) | [form ]
powder | [color ]
white to dark brown | [InChI]
1S/C16H17N5O2/c1-8-9(2)17-16(20-14(8)22)21-15-18-10(3)12-6-5-11(23-4)7-13(12)19-15/h5-7H,1-4H3,(H2,17,18,19,20,21,22) | [InChIKey]
QQJIYKXTEMDJFM-UHFFFAOYSA-N | [SMILES]
CC1=NC(NC(NC(C)=C2C)=NC2=O)=NC3=CC(OC)=CC=C31 |
| Hazard Information | Back Directory | [Uses]
Madrasin has been used as a spliceosome inhibitor to inhibit pre-mRNA processing in 3T3-L1 cells. | [Definition]
ChEBI: 2-[(7-methoxy-4-methyl-2-quinazolinyl)amino]-5,6-dimethyl-1H-pyrimidin-4-one is a member of quinazolines. | [Biochem/physiol Actions]
Madrasin is a potent and cell penetrant splicing inhibitor that interferes with the early stages of spliceosome assembly. Madrasin stalls spliceosome assembly at the A complex. | [storage]
Store at -20°C |
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Sigma-Aldrich
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