| Identification | Back Directory | [Name]
melarsonic acid | [CAS]
37526-80-0 | [Synonyms]
melarsonic acid
1,3,2-Dithiarsolane-4,5-dicarboxylic acid, 2-[4-[(4,6-diamino-1,3,5-triazin-2-yl)amino]phenyl]- | [Molecular Formula]
C13H13AsN6O4S2 | [MDL Number]
MFCD00866618 | [MOL File]
37526-80-0.mol | [Molecular Weight]
456.33 |
| Chemical Properties | Back Directory | [Boiling point ]
850.4±75.0 °C(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
2.31±0.40(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
Melarsonyl (Melarsonic acid) is an anthelmintic agent which can inhibit parasite potently. | [in vivo]
For acute infections produced by T. brucei brucei GVR, Potassium Melarsonyl exhibits trypanocidal activities. Potassium Melarsonyl (Trimelarsan) cures less than 50% mice at a dose of 25 μmol/kg for 4 consecutive days. At 60 μmol/kg, it cures all the mice in a chronic-infection model[1]. | [storage]
Store at -20°C | [References]
[1] Loiseau PM, et al. Contribution of dithiol ligands to in vitro and in vivo trypanocidal activities of dithiaarsanes and investigation of ligand exchange in an aqueous solution. Antimicrob Agents Chemother. 2000 Nov;44(11):2954-61. DOI:10.1128/AAC.44.11.2954-2961.2000 |
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