| Identification | Back Directory | [Name]
D-Ala-Lys-AMCA | [CAS]
375822-19-8 | [Synonyms]
D-Ala-Lys-AMCA
L-Lysine, D-alanyl-N6-[(7-amino-4-methyl-2-oxo-2H-1-benzopyran-3-yl)acetyl]- (9CI) | [Molecular Formula]
C21H28N4O6 | [MDL Number]
MFCD32062745 | [MOL File]
375822-19-8.mol | [Molecular Weight]
432.47 |
| Hazard Information | Back Directory | [Uses]
D-Ala-Lys-AMCA is a known proton-coupled oligopeptide transporter 1 (PEPT1) substrate that emits blue fluorescence. D-Ala-Lys-AMCA may be transported into liver cancer cells and Caco-2 cells based on fluorescence analysis. D-Ala-Lys-AMCA can be used for characterizing PEPT1-specific substrates or inhibitors[1][2]. | [References]
[1] Gong Y, et al. Specific expression of proton-coupled oligopeptide transporter 1 in primary hepatocarcinoma-anovel strategy for tumor-targeted therapy. Oncol Lett. 2017 Oct;14(4):4158-4166. DOI:10.3892/ol.2017.6724
[2] Groneberg DA, et al. Intestinal peptide transport: ex vivo uptake studies and localization of peptide carrier PEPT1. Am J Physiol Gastrointest Liver Physiol. 2001 Sep;281(3):G697-704. DOI:10.1152/ajpgi.2001.281.3.G697 |
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