| Identification | Back Directory | [Name]
1-(4-Hydroxy-2-Methoxyphenyl)
-3-(4-hydroxy-3-prenylphenyl)propane | [CAS]
376362-03-7 | [Synonyms]
2'-O-Methylbroussonin C
1-(4-Hydroxy-2-Methoxyphenyl)
-3-(4-hydroxy-3-prenylphenyl)propane
4-(3-(4-Hydroxy-2-Methoxyphenyl)propyl)-2-(3-Methylbut-2-en-1-yl)phenol | [Molecular Formula]
C21H26O3 | [MDL Number]
MFCD20274997 | [MOL File]
376362-03-7.mol | [Molecular Weight]
326.429 |
| Chemical Properties | Back Directory | [Melting point ]
85-86 °C | [Boiling point ]
490.3±40.0 °C(Predicted) | [density ]
1.102±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Powder | [pka]
9.78±0.20(Predicted) |
| Hazard Information | Back Directory | [Uses]
1-(4-Hydroxy-2-methoxyphenyl)-3-(4-hydroxy-3-prenylphenyl), isolated from Broussonetia kazinoki, shows in vitro inhibition of protein tyrosine phosphatase 1B (PTP1B) with an IC50 of 13.00 μM. PTP1B is a negative regulator of insulin action and an important mediator in the pathogenesis of insulinresistance and non-insulin dependent diabetes mellitus. PTP1B is regarded as a significant target for type 2 diabetes[1]. | [References]
[1] Jing-Jing Xue, et al. Flavans and diphenylpropanes with PTP1B inhibition from Broussonetia kazinoki. Fitoterapia. 2018 Oct;130:37-42. DOI:10.1016/j.fitote.2018.08.001 |
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