| Identification | Back Directory | [Name]
1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione | [CAS]
376382-11-5 | [Synonyms]
BRD 7389
BRD 7389
(BRD7389)
BRD7389 >=98% (HPLC)
Insulin Expression Inducer, BRD7389
1-Phenethylamino-3H-naphtho[1,2,3-de]quinoline-2,7-dione
1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione
1-[(2-Phenylethyl)amino]-naphtho-3H-[1,2,3-de]quinoline-2,7-dione
Insulin Expression Inducer, BRD7389 - CAS 376382-11-5 - Calbiochem
3H-Naphtho[1,2,3-de]quinoline-2,7-dione, 1-[(2-phenylethyl)aMino]- | [Molecular Formula]
C24H18N2O2 | [MDL Number]
MFCD02924820 | [MOL File]
376382-11-5.mol | [Molecular Weight]
366.41 |
| Chemical Properties | Back Directory | [Boiling point ]
655.0±55.0 °C(Predicted) | [density ]
1.35±0.1 g/cm3(Predicted) | [storage temp. ]
Store at +4°C | [solubility ]
DMSO: >20mg/mL | [form ]
powder | [pka]
11.31±0.40(Predicted) | [color ]
orange | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| Hazard Information | Back Directory | [Description]
BRD7389 is an inhibitor of ribosomal S6 kinases (RSKs; IC50s = 1.5, 2.4, and 1.2 μM for RSK1, RSK2, and RSK3, respectively). Through this action, BRD7389 causes mouse αTC1 pancreatic α cells to adopt several morphological and gene expression features of β cells, including increased insulin expression. BRD7389 also enhances glucose-stimulated insulin and glucagon secretion by pancreatic islet cells isolated from human donors with a low body mass index. | [Uses]
BRD7389 is a specific RSK family kinase inhibitor with IC50s of 1.5 μM, 2.4 μM, and 1.2 μM for RSK1, RSK2, and RSK3, respectively. BRD7389 is a small-molecule inducer of insulin expression in pancreatic α-cells[1]. | [Definition]
ChEBI: LSM-4550 is a member of anthracenes. | [IC 50]
RSK1: 1.5 μM (IC50); RSK2: 2.4 μM (IC50); RSK3: 1.2 μM (IC50); CDK5/p35: 6.5 μM (IC50); DRAK1: 2.8 μM (IC50); FLT3: 3.5 μM (IC50); PIM1: 3.7 μM (IC50); PKG1α: 6.5 μM (IC50); SGK: 13.8 μM (IC50) | [storage]
Store at -20°C | [References]
1) Fomina-Yadlin et al. (2010), Small molecule inducers of insulin expression in pancreatic alpha-cells; Proc. Natl. Acad. Sci. USA, 107 15099
2) Choudhary et al. (2014), Quantitative-proteomic comparison of alpha and Beta cells to uncover novel targets for lineage reprogramming; PLoS One, 9(4) e95194
3) Park and Cho (2012), EGFR and PKC are involved in the activation of ERK1/2 and p90 RSK and the subsequent proliferation of SNU-470 colon cancer cells by muscarinic acetylcholine receptors; Mol. Cell. Biochem., 370 191 |
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