| Identification | Back Directory | [Name]
11-DEOXY PROSTAGLANDIN F1ALPHA | [CAS]
37785-98-1 | [Synonyms]
11-deoxy Prostaglandin F1α
HYBPXYQCXNOTFK-DUSCRHDRSA-N
11-DEOXY PROSTAGLANDIN F1ALPHA
9ALPHA,15S-DIHYDROXY-PROST-13E-EN-1-OIC ACID | [Molecular Formula]
C20H36O4 | [MDL Number]
MFCD00797651 | [MOL File]
37785-98-1.mol | [Molecular Weight]
340.5 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: >50 mg/ml (from PGF1a); DMSO: >50 mg/ml (from PGF1a); Ethanol: >75 mg/ml (from PGF1a); PBS pH 7.2: >2 mg/ml (from PGF1a) | [form ]
A crystalline solid |
| Hazard Information | Back Directory | [Description]
11-deoxy PGF1α is a synthetic analog of PGF1α. In whole animal studies, a dose of 32 mg/kg inhibited gastric acid secretion by 35%. 11-deoxy PGF1α is also known to cause rat uterine contractions at a dose 0.3 times that of PGF1α. It also exhibits vasopressor and bronchoconstrictor activities at about half the potency of PGF2α in guinea pigs. | [Uses]
11-deoxy Prostaglandin F1α (11-deoxy PGF1α) is an analog of prostaglandin F1α, exhibits side effects on intestines and causes the uterine contraction. 11-deoxy Prostaglandin F1α exhibits activity as vasopressor and bronchoconstrictor[1][2]. | [Definition]
ChEBI: 11-Deoxy-PGF1alpha is a prostanoid. | [in vivo]
11-deoxy PGF1α (0-10 mg/kg, i.v., single dose) stimulates the uterine contraction in pregnant SD rats, while reveals slightly efficacy on hamster fertility[1]. | Animal Model: | pregnant Sprague-Dawley rats[1] | | Dosage: | 0-10 mg/kg | | Administration: | i.v., single dose | | Result: | Stimulated uterine contraction 3 times active as PGF1α. |
| [References]
[1] Broughton BJ, et al., Uterine stimulant action of some omega-chain modified (+)-11-deoxyprostaglandins. Prostaglandins. 1981 Jul;22(1):53-64. DOI:10.1016/0090-6980(81)90053-8
[2] Hall DW, et al., Structure-activity relationships in a series of 11-deoxy prostaglandins. Prostaglandins. 1976 Mar;11(3):573-87. DOI:10.1016/0090-6980(76)90106-4 |
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