| Identification | Back Directory | [Name]
2-(7-methoxy-4-methylquinazolin-2-yl)guanidine | [CAS]
37836-90-1 | [Synonyms]
MPO inhibitor 28
Myeloperoxidase inhibitor 28
2-(7-methoxy-4-methylquinazolin-2-yl)guanidine
Guanidine, N-(7-methoxy-4-methyl-2-quinazolinyl)- | [Molecular Formula]
C11H13N5O | [MOL File]
37836-90-1.mol | [Molecular Weight]
231.25 |
| Chemical Properties | Back Directory | [Boiling point ]
442.7±37.0 °C(Predicted) | [density ]
1.40±0.1 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,2-8°C | [solubility ]
DMSO:34.37(Max Conc. mg/mL);148.6(Max Conc. mM) | [form ]
A solid | [pka]
7.83±0.30(Predicted) | [color ]
Off-white to light yellow | [InChI]
1S/C11H13N5O/c1-6-8-4-3-7(17-2)5-9(8)15-11(14-6)16-10(12)13/h3-5H,1-2H3,(H4,12,13,14,15,16) | [InChIKey]
ZJBMSSBTCGJZEE-UHFFFAOYSA-N | [SMILES]
N(c1nc2c(c(n1)C)ccc(c2)OC)\C(=N\[H])\N |
| Hazard Information | Back Directory | [Uses]
MPO-IN-28 is a selective myeloperoxidase (MPO) inhibitor with an IC50 of 44 nM. MPO-IN-28 can effectively inhibit MPO-mediated low-density lipoprotein oxidation with an IC50 of 90 nM[1]. | [Biological Activity]
Compound 18 is an agonist of Aedes aegypti mosquitoes NPY-like receptor 7 (NPYLR7) th at inhibit mosquito attraction to humans and other hosts. Compound 18 suppresses biting and blood-feeding on a live host. AlsoIt (MPO-IN-28) is a potent myeloperoxidase (MPO) inhibitor with an IC50 of 44 nM. | [References]
[1] Soubhye J, et al. Discovery of Novel Potent Reversible and Irreversible Myeloperoxidase Inhibitors Using Virtual Screening Procedure. J Med Chem. 2017 Aug 10;60(15):6563-6586. DOI:10.1021/acs.jmedchem.7b00285 |
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