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3785-21-5

3785-21-5 Structure

3785-21-5 Structure
IdentificationBack Directory
[Name]

Butanilicaine hydrochloride
[CAS]

3785-21-5
[Synonyms]

butanilicaine
Butanilicaina
Butacetoluide
Butanilicainum
3003 BUTANILICAINE
Butanilicainum [inn-latin]
2081-65-4 (Phosphate[1:1])
Butanilicaina [inn-spanish]
BUTANILICAINE HYDROCHLORIDE
6027-28-7 (Mono-hydrochloride)
2-butylamino-6-chloroacet-o-toluidide
2-Butylamino-6'-chloro-o-acetotoluidide
2-Butylamino-N-(2-chloro-6-methylphenyl)acetamide
2-(Butylamino)-N-(2-methyl-6-chlorophenyl)acetamide
Acetamide, 2-(butylamino)-N-(2-chloro-6-methylphenyl)-
2-(Butylamino)-N-(2-chloro-6-methylphenyl)acetamide hydrochloride
[Molecular Formula]

C13H19ClN2O
[MDL Number]

MFCD00864434
[MOL File]

3785-21-5.mol
[Molecular Weight]

254.76
Chemical PropertiesBack Directory
[Melting point ]

45-46°
[Boiling point ]

bp0.001 145°; bp0.5 166-167°
[density ]

1.129±0.06 g/cm3(Predicted)
[storage temp. ]

Refrigerator
[solubility ]

DMSO (Slightly), Methanol (Slightly)
[form ]

Solid
[pka]

13.41±0.70(Predicted)
[color ]

Pale Brown to Light Brown
[NIST Chemistry Reference]

Butanilicaine(3785-21-5)
Hazard InformationBack Directory
[Originator]

Butanilicaine,Enreco, INC
[Uses]

Butanilicaine Hydrochloride, is a local anesthetic.
[Definition]

ChEBI: An amino acid amide amide in which N-butylglycine and 2-chloro-6-methylaniline have combined to form the amide bond; used as a local anaesthetic (amide caine).
[Manufacturing Process]

To a solution of 4-bromo-2-methylaniline is added 13 g of chloroacetyl chloride. After the reaction is finished to the mixture id added a solution of 33 g sodium acetate in 138 ml of water. Chloroacetic acid 4-bromo-2- methylanilide is filtered; yield 24 g, M.P. 135°C (crystallization from ethanol).
20 g of chloroacetic acid 4-bromo-2-methylanilide is dissolved in 200 ml of butylamine. After about 15 hours to the solution is added 2 N hydrochloric acid. Butylaminoacetic acid 4-bromo-2-methylanilide hydrochloride is removed by suction and washed with water; yield 90%, M.P. 252-253°C (from methanol).
[Therapeutic Function]

Local anesthetic
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