| Identification | Back Directory | [Name]
CB-6673567
(CB6673567) | [CAS]
379218-90-3 | [Synonyms]
CB-6673567
(CB6673567)
1,3-Benzodioxol-4-ol, 5-(1'-phenyl[4,4'-bi-1H-pyrazol]-3-yl)- | [Molecular Formula]
C19H14N4O3 | [MOL File]
379218-90-3.mol | [Molecular Weight]
346.34 |
| Hazard Information | Back Directory | [Uses]
CB-6673567 is a selective AC1 inhibitor with an IC50 of 77 μM .CB-6673567blocks the choline-induced cAMP increase and can be used for cardiovascular diseases research[1]. | [References]
[1] Brand CS, et al. Isoform selectivity of adenylyl cyclase inhibitors: characterization of known and novel compounds. J Pharmacol Exp Ther. 2013 Nov;347(2):265-75. DOI:10.1124/jpet.113.208157
[2] Cheng Q, et al. Activation of α7 nicotinic acetylcholine receptors increases intracellular cAMP levels via activation of AC1 in hippocampal neurons. Neuropharmacology. 2015 Aug;95:405-14. DOI:10.1016/j.neuropharm.2015.04.016 |
|
|