| Identification | Back Directory | [Name]
1-(4-bromophenyl)-2-[2-(2-thienyl)-4H-[1,2,4]triazolo[1,5-a]benzimidazol-4-yl]ethanone | [CAS]
380645-50-1 | [Synonyms]
LX-3
1-(4-bromophenyl)-2-[2-(2-thienyl)-4H-[1,2,4]triazolo[1,5-a]benzimidazol-4-yl]ethanone | [Molecular Formula]
C20H13BrN4OS | [MOL File]
380645-50-1.mol | [Molecular Weight]
437.31 |
| Hazard Information | Back Directory | [Description]
LX-3 is a selective activator of the p38 mitogen-activated protein kinase (MAPK) pathway, which de-represses a subset of endogenous genes repressed by DNA methylation. | [Uses]
LX-3 is a selective activator of the p38 MAPK signaling pathway and activates EGFP reporter genes that are silenced by DNA methylation, such as TNF, EGR1, LY6K, and ISG20[1]. | [References]
[1] Li X, et al., Small molecules capable of activating DNA methylation-repressed genes targeted by the p38 mitogen-activated protein kinase pathway. J Biol Chem. 2018 May 11;293(19):7423-7436. DOI:10.1074/jbc.RA117.000757 |
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