| Identification | Back Directory | [Name]
5-BROMO-3-IODO-PYRIDIN-2-OL | [CAS]
381233-75-6 | [Synonyms]
5-bromo-3-iodopyrazin-2-ol
5-bromo-4-iodopyridin-2(1H)-one
5-BroMo-3-iodo-1H-pyridin-2-one
5-BroMo-3-iodopyridin-2(1H)-one
5-Bromo-2-hydroxy-3-iodopyridine
2-Hydroxy-3-iodo-5-bromopyridine
2(1H)-Pyridinone, 5-broMo-3-iodo-
5-Bromo-3-iodo-2-hydroxypyridine,97%
5-Bromo-2-hydroxy-3-iodopyridine 95+%
5-BroMo-3-iodo-2-hydroxypyridine, 97%
5‐bromo‐3‐iodo‐1,2‐dihydropyridin‐2‐one
5-bromo-2-hydroxy-3-iodopyridine, 5-bromo-3-iodopyridin-2-ol | [Molecular Formula]
C5H3BrINO | [MDL Number]
MFCD08688586 | [MOL File]
381233-75-6.mol | [Molecular Weight]
299.9 |
| Chemical Properties | Back Directory | [Melting point ]
226-227℃ | [Boiling point ]
307.9±42.0 °C(Predicted) | [density ]
2.55±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C(protect from light) | [pka]
8.52±0.10(Predicted) | [Appearance]
Light yellow to yellow Solid | [Sensitive ]
Light Sensitive | [InChI]
InChI=1S/C5H3BrINO/c6-3-1-4(7)5(9)8-2-3/h1-2H,(H,8,9) | [InChIKey]
WAUPPDAXWKLNNU-UHFFFAOYSA-N | [SMILES]
C1(=O)NC=C(Br)C=C1I | [CAS DataBase Reference]
381233-75-6 |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 5-bromo-3-iodopyridin-2(1H)-one from 2-hydroxy-5-bromopyridine: 5-bromo-2-hydroxypyridine (2.5 g, 14.4 mmol), iodosuccinimide (4.7 g, 20.9 mmol), and acetonitrile (40 mL) were mixed, and the reaction was stirred for 20 min at 82 °C. After completion of the reaction, the mixture was cooled to room temperature and the solid was collected by filtration. The filter cake was recrystallized with ethyl acetate to afford the target product 5-bromo-2-hydroxy-3-iodopyridine (4.0 g) in 92.6% yield. | [References]
[1] Patent: CN108084186, 2018, A. Location in patent: Paragraph 0187-0188
[2] Synlett, 2003, # 11, p. 1678 - 1682
[3] Journal of Medicinal Chemistry, 2015, vol. 58, # 4, p. 1644 - 1668
[4] Patent: WO2015/132727, 2015, A1. Location in patent: Page/Page column 22; 28
[5] Heterocycles, 2002, vol. 57, # 1, p. 55 - 71 |
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| Company Name: |
SAKEM LLP
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| Tel: |
+91-9676889998 +91-9676889998 |
| Website: |
www.sakem.co.in |
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