| Identification | Back Directory | [Name]
4-METHYL-2-(5-PHENYL-1H-PYRAZOL-3-YL)PHENOL | [CAS]
38214-71-0 | [Synonyms]
VRT-532
CFpot 532
VRT 532,VRT532
VRT-532 >=98% (HPLC)
4-METHYL-2-(5-PHENYL-1H-PYRAZOL-3-YL)PHENOL
PHENOL, 4-METHYL-2-(5-PHENYL-1H-PYRAZOL-3-YL)- | [Molecular Formula]
C16H14N2O | [MDL Number]
MFCD01308792 | [MOL File]
38214-71-0.mol | [Molecular Weight]
250.3 |
| Chemical Properties | Back Directory | [Melting point ]
153-154 °C(Solv: acetic acid (64-19-7)) | [Boiling point ]
472.9±40.0 °C(Predicted) | [density ]
1.213±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO: >20mg/mL | [form ]
solid | [pka]
9.16±0.43(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
VRT-532 (CFpot-532) is a potent is a potent CFTR modulator. VRT-532 enhances channel activity in G551D-CFTR and intrinsic ATPase activity of G551D-CFTR. VRT-532 has the potential for the research of cystic fibrosis[1][2]. | [References]
[1] Pasyk S, et al. Direct interaction of a small-molecule modulator with G551D-CFTR, a cystic fibrosis-causing mutation associated with severe disease. Biochem J. 2009 Feb 15;418(1):185-90. DOI:10.1042/BJ20081424
[2] Wang Y, et al. Correctors promote maturation of cystic fibrosis transmembrane conductance regulator (CFTR)-processing mutants by binding to the protein. J Biol Chem. 2007 Nov 16;282(46):33247-33251. DOI:10.1074/jbc.C700175200 |
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|