| Identification | Back Directory | [Name]
dehydrocurdione | [CAS]
38230-32-9 | [Synonyms]
dehydrocurdione
6,10-Dimethyl-3-isopropylidene-6-cyclodecene-1,4-dione
(6Z,10S)-3-Isopropylidene-6,10-dimethyl-6-cyclodecene-1,4-dione
6-Cyclodecene-1,4-dione, 6,10-dimethyl-3-(1-methylethylidene)-, (6E,10S)- | [Molecular Formula]
C15H22O2 | [MDL Number]
MFCD03792779 | [MOL File]
38230-32-9.mol | [Molecular Weight]
234.33 |
| Hazard Information | Back Directory | [Uses]
Dehydrocurdione, a zedoary-derived sesquiterpene, induces heme oxygenase (HO)-1, an antioxidative enzyme, in RAW 264.7 macrophages. Dehydrocurdione interacts with Keap1, resulting in Nrf2 translocation followed by activation of the HO-1 E2 enhancer. Dehydrocurdione suppresses lipopolysaccharide-induced NO release, a marker of inflammation. Anti-inflammatory activity[1][2]. | [in vivo]
Dehydrocurdione (P.o ;120 mg/kg, daily for 12 days) significantly reduces chronic adjuvant arthritis[2].
Dehydrocurdione (200 mg/kg; p.o.; Sprague-Dawley rats) dose-dependently inhibits carrageenan-induced paw edema[2]. | Animal Model: | Wistar rats[2] | | Dosage: | 120 mg/kg | | Administration: | P.o ; daily for 12 days | | Result: | Significantly reduces chronic adjuvant arthritis.
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| [References]
[1] Ohnishi M, et al. Curcuma sp.-derived dehydrocurdione induces heme oxygenase-1 through a Michael reaction between its α, β-unsaturated carbonyl and Keap1. Phytother Res. 2018;32(5):892-897. DOI:10.1002/ptr.6028
[2] Yoshioka T, et al. Antiinflammatory potency of dehydrocurdione, a zedoary-derived sesquiterpene. Inflamm Res. 1998;47(12):476-481. DOI:10.1007/s000110050361 |
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