| Identification | Back Directory | [Name]
Propanedioic acid, ((2-amino-3-hydroxy-1-oxopropyl)amino)(2-(5-(aminom ethyl)-2,5-dihydro-4-hydroxy-2-oxo-1H-pyrrol-3-yl)-2-oxoethyl)- | [CAS]
38249-71-7 | [Synonyms]
Malonomicin
Antibiotic K-16
Propanedioic acid, ((2-amino-3-hydroxy-1-oxopropyl)amino)(2-(5-(aminom ethyl)-2,5-dihydro-4-hydroxy-2-oxo-1H-pyrrol-3-yl)-2-oxoethyl)-
2-[(2-Amino-3-hydroxy-1-oxopropyl)amino]-2-[2-[5-(aminomethyl)-2,5-dihydro-4-hydroxy-2-oxo-1H-pyrrol-3-yl]-2-oxoethyl]propanedioic acid
Propanedioic acid, 2-[(2-amino-3-hydroxy-1-oxopropyl)amino]-2-[2-[5-(aminomethyl)-2,5-dihydro-4-hydroxy-2-oxo-1H-pyrrol-3-yl]-2-oxoethyl]- | [Molecular Formula]
C13H18N4O9 | [MDL Number]
MFCD01939885 | [MOL File]
38249-71-7.mol | [Molecular Weight]
374.3 |
| Chemical Properties | Back Directory | [Boiling point ]
934.544±65.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.706±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [pka]
1.525±0.10(predicted) |
| Hazard Information | Back Directory | [Uses]
Malonomicin (Antibiotic K16) is an antibiotic with anti-protozoa and anti-trypanosome activities. Malonomicin also shows anti-trypanosome activity in vivo[1][2]. | [in vivo]
Malonomicin (30 mg/kg; i.p., once) eliminates the infection status of trypanosoma infected-mice and shows no harmful effects with daily dose of 50 mg/kg[2]. | Animal Model: | Mice with Trypanosoma congolense infection[2] | | Dosage: | 30 mg/kg | | Administration: | Intraperitoneal injection; 30 mg/kg, once | | Result: | Eliminated all trypanosomes from in the blood of infected mice. |
| [IC 50]
Trypanosoma | [References]
[1] Emilio L. Ghisalberti. Bioactive Tetramic Acid Metabolites. Studies in Natural Products Chemistry. Volume 28, Part I, 2003, Pages 109-163.
[2] Ottens Hendrik and Vos Cornelis. Preparation of an antibiotic for the treatment of trypanosomiasis. NL6701356. 1967. |
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