| Identification | Back Directory | [Name]
Isopenbutolol | [CAS]
38363-41-6 | [Synonyms]
Ccris 2854
d-Penbutolol
Isopenbutolol
(R)-Penbutolol
(+)-PENBUTOLOL
(+)-Isopenbutolol
(+)-(R)-Penbutolol
(+)-Isopenbutolol)
R-(+)-Isopenbutolol
(+)-Penbutolol ((R)-Penbutolol
(+)-Penbutolol (Synonyms: (R)-Penbutolol
(2R)-1-(tert-Butylamino)-3-(2-cyclopentylphenoxy)-2-propanol
[R,(+)]-1-(tert-Butylamino)-3-(2-cyclopentylphenoxy)-2-propanol
2-Propanol, 1-(2-cyclopentylphenoxy)-3-[(1,1-dimethylethyl)amino]-, (R)-
2-Propanol, 1-(2-cyclopentylphenoxy)-3-[(1,1-dimethylethyl)amino]-, (2R)-
2-Propanol, 1-(2-cyclopentylphenoxy)-3-[(1,1-dimethylethyl)amino]-, (2R)- (9CI) | [Molecular Formula]
C18H29NO2 | [MOL File]
38363-41-6.mol | [Molecular Weight]
291.43 |
| Chemical Properties | Back Directory | [Boiling point ]
438.2±40.0 °C(Predicted) | [density ]
1.030±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
13.90±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Definition]
ChEBI: (+)-Penbutolol is an aromatic ether. | [Biological Activity]
Isopenbutololl is a beta-adrenergic antagonist with an IC50 value of 0.74 μM. It is also an optical isomer of (-)-penbutolol, which blocks Na+ channels. | [in vitro]
(+)-penbutolol on the [Ca 2+ ] i -increase induced by LPC is concentration-dependent.
(+) -penbutolol inhibits the rounding of cells dose dependently (8±4%, 56±4% and 66±2% at the concentrations of 10 -6 M, 5×10 -6 M and 10 -5 M, respectively). | [target]
IC50: 0.74 μM (β-adrenoceptor). | [storage]
Store at -20°C |
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