| Identification | Back Directory | [Name]
3-chloro-N-hydroxy-1-benzothiophene-2-carboxamide | [CAS]
383892-69-1 | [Synonyms]
J1075
J-1075
J 1075
3-chloro-N-hydroxy-1-benzothiophene-2-carboxamide | [Molecular Formula]
C9H6ClNO2S | [MOL File]
383892-69-1.mol | [Molecular Weight]
227.67 |
| Hazard Information | Back Directory | [Description]
J1075 is an inhibitor of histone deacetylase 8 (HDAC8). | [Uses]
J1075 is a selective Schistosoma mansoni HDAC8 inhibitor (with decreased affinity for human HDAC8). J1075 can induce apoptosis (Apoptosis) and death in schistosome cells. J1075 holds research value in the field of anti-parasitic agents[1]. | [IC 50]
HDAC8 | [References]
[1] Marek M, et al. Structural basis for the inhibition of histone deacetylase 8 (HDAC8), a key epigenetic player in the blood fluke Schistosoma mansoni. PLoS Pathog. 2013;9(9):e1003645. DOI:10.1371/journal.ppat.1003645 |
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