| Identification | Back Directory | [Name]
2-chloro-N-[[4-(dimethylamino)phenyl]methyl]-N-[3-phenyl-3-(4-propan-2-yloxyphenyl)propyl]acetamide | [CAS]
384361-79-9 | [Synonyms]
2-chloro-N-[[4-(dimethylamino)phenyl]methyl]-N-[3-phenyl-3-(4-propan-2-yloxyphenyl)propyl]acetamide | [Molecular Formula]
C29H35ClN2O2 | [MOL File]
384361-79-9.mol | [Molecular Weight]
479.05 |
| Hazard Information | Back Directory | [Description]
NPD926 is an inducer of cancel cell death. NPD926 sensitized cells to inhibitors of system x(c)?, a cystine-glutamate antiporter considered to be a potential therapeutic target in cancers including cancer stem cells. Induction of excessive levels of reactive oxygen species (ROS) by small-molecule compounds has been considered a potentially effective therapeutic strategy against cancer cells, which are often subjected to chronic oxidative stress. | [Uses]
NPD926 is a small molecule that targets glutathione and induces cancer cell death. The Xc- system and glutathione are therapeutic targets in cancer. NPD926 causes cellular glutathione depletion and subsequent generation of reactive oxygen species (ROS), thereby sensitizing fibroblasts to Xc- system inhibitors. NPD926 is a ROS inducer with anticancer activity.[1]. | [References]
[1] A small molecule that induces reactive oxygen species via cellular glutathione depletion |
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