| Identification | Back Directory | [Name]
BMS-36313 | [CAS]
384829-65-6 | [Synonyms]
BMS-36313
BMS363131
BMS-363131
BMS 363131
2-Azetidinecarboxylic acid, 3-[[(3R)-1-(aminoiminomethyl)-3-piperidinyl]methyl]-4-oxo-1-[[4-(1-oxo-6-phenylhexyl)-1-piperazinyl]carbonyl]-, (2S,3R)- | [Molecular Formula]
C28H40N6O5 | [MOL File]
384829-65-6.mol | [Molecular Weight]
540.65 |
| Hazard Information | Back Directory | [Uses]
BMS-363131 is a selective inhibitor for tryptase, with an IC50 <1.7 nM. BMS-363131 is hydrolytic stable at pH=7 and pH=9. BMS-363131 attenuates the astham in a guinea pig model[1]. | [References]
[1] Slusarchyk WA, et al., Synthesis of potent and highly selective inhibitors of human tryptase. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3235-8. DOI:10.1016/s0960-894x(02)00689-3 |
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