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386704-15-0

386704-15-0 Structure

386704-15-0 Structure
IdentificationBack Directory
[Name]

METHYL6-(TRIFLUOROMETHYL)NICOTINOYLACETATE
[CAS]

386704-15-0
[Synonyms]

11β-HSD1-IN-8
Methyl 3-oxo-3-(6-(tri?uoromethyl)pyrid in-3-yl)propanoate
Methyl 3-oxo-3-[6-(trifluoroMethyl)pyridin-3-yl]propanoate
Methyl3-oxo-3-[6-(trifluoromethyl)pyridin-3-yl]propanoate97%
Methyl 3-oxo-3-[6-(trifluoromethyl)pyridin-3-yl]propanoate 97%
3-Pyridinepropanoic acid, β-oxo-6-(trifluoromethyl)-, methyl ester
3-oxo-3-[6-(trifluoromethyl)-3-pyridinyl]propanoic acid methyl ester
Methyl 3-oxo-3-[6-(trifluoromethyl)pyridin-3-yl]propionate, Methyl [6-(trifluoromethyl)nicotinoyl]acetate
[Molecular Formula]

C10H8F3NO3
[MDL Number]

MFCD01862654
[MOL File]

386704-15-0.mol
[Molecular Weight]

247.17
Chemical PropertiesBack Directory
[Melting point ]

60-62°C
[storage temp. ]

Inert atmosphere,Room Temperature
[form ]

Solid
[color ]

Off-white to light yellow
Safety DataBack Directory
[Hazard Codes ]

Xi
[HS Code ]

2933399990
Hazard InformationBack Directory
[Uses]

11β-HSD1-IN-8 (compound c6a) is a 11β HSD1 inhibitor with an IC50 value of 2.3 μM for human 11β HSD1. 11β-HSD1-IN-8 can be used for the research of diabetes and cognitive decline[1].
[References]

[1] Naredo-Gonzalez G, et al. Non-invasive in vivo assessment of 11β-hydroxysteroid dehydrogenase type 1 activity by 19F-Magnetic Resonance Spectroscopy. Sci Rep. 2022 Sep 29;12(1):16268. DOI:10.1038/s41598-022-18740-5
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