| Identification | Back Directory | [Name]
8-AMINOADENOSINE | [CAS]
3868-33-5 | [Synonyms]
NSC 90394
8-NH2-Ado
8-Amionadenosine
8-AMINOADENOSINE
Adenosine, 8-amino-
8-Amino-D-adenosine
8-AMINOADENOSINE USP/EP/BP
6,8-DiaMino-9-β-D-ribofuranosyl- 9H-purine
6,8-Diamino-9-beta-D-ribofuranosyl-9H-purine
9H-Purine, 6,8-diamino-9-.beta.-D-ribofuranosyl-
2-(6,8-diamino-9-purinyl)-5-(hydroxymethyl)oxolane-3,4-diol
(2R,3R,4S,5R)-2-(6,8-Diamino-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol | [Molecular Formula]
C10H14N6O4 | [MDL Number]
MFCD00047230 | [MOL File]
3868-33-5.mol | [Molecular Weight]
282.26 |
| Chemical Properties | Back Directory | [Melting point ]
180-185°C dec. | [Boiling point ]
747.1±70.0 °C(Predicted) | [density ]
2.25 | [storage temp. ]
-20°C Freezer | [solubility ]
H2O: soluble2mg/mL, clear (warmed) | [form ]
powder | [pka]
13.07±0.70(Predicted) | [color ]
white to beige | [Water Solubility ]
H2O: 2mg/mL, clear (warmed) |
| Hazard Information | Back Directory | [Chemical Properties]
Off-White Solid | [Uses]
The purine nucleoside analog | [Biological Activity]
8-Aminoadenosinea ribose nucleosidereduces cellular ATP levels and inhibits mRNA synthesis. 8-Aminoadenosine also inhibits transcription and polyadenylation. 8-Aminoadenosine potently inhibits varies breast cancer cell lines proliferation and activates cell death independent of p53. 8-NH2-Ado is highly cytotoxic to other cancer cell lines. | [IC 50]
mTOR |
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