| Identification | Back Directory | [Name]
CUCURBITACIN D | [CAS]
3877-86-9 | [Synonyms]
Cucurbit D
elatericinea
ELATERICIN A
CUCURBITACIN D
cucurbitacine(d)
20,25-tetrahydroxy-ph
CUCURBITACIN D WITH HPLC
(10α,23E)-2β,16α,20,25-Tetrahydroxy-9β-methyl-19-norlanosta-5,23-diene-3,11,22-trione
(9β,10α,23E)-2β,16α,20,25-Tetrahydroxy-9-methyl-19-norlanosta-5,23-diene-3,11,22-trione
19-Norlanosta-5,23-diene-3,11,22-trione, 2,16,20,25-tetrahydroxy-9-methyl-, (2β,9β,10α,16α,23E)-
17-[(3E)-1,5-Dihydroxy-1,5-dimethyl-2-oxohex-3-en-1-yl]-2,16-dihydroxy-4,4,9,14-tetramethylestr-5-ene-3,11-dione | [Molecular Formula]
C30H44O7 | [MDL Number]
MFCD01711333 | [MOL File]
3877-86-9.mol | [Molecular Weight]
516.67 |
| Chemical Properties | Back Directory | [Melting point ]
151.5°C | [Boiling point ]
521.47°C (rough estimate) | [density ]
1.0814 (rough estimate) | [refractive index ]
1.5820 (estimate) | [storage temp. ]
4°C, protect from light | [solubility ]
Soluble in ethanol and methan | [form ]
powder | [pka]
12.66±0.29(Predicted) | [color ]
White | [LogP]
1.480 (est) | [CAS DataBase Reference]
3877-86-9 |
| Hazard Information | Back Directory | [Uses]
Cucurbitacin D acts as a potential potent anti-cancer agent in various cervical cancers through induction of apopotosis. | [Definition]
ChEBI: A cucurbitacin in which a lanostane skeleton is multi-substituted with hydroxy, methyl and oxo substituents, with unsaturation at positions 5 and 23. | [in vivo]
Cucurbitacin D (1 mg/kg, intratumoral injection, three times a week for four weeks) inhibits tumor proliferation in mice[3]. | Animal Model: | Xenograft cervical cancer cell model in nude mice[3] | | Dosage: | 1 mg/kg; three times a week; four weeks | | Administration: | Intratumoral injection | | Result: | Reduced tumor volume and weight, and the expression of pAKT and pSTAT3 proteins was significantly reduced. |
| [IC 50]
HSP90 | [storage]
4°C, protect from light |
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