| Identification | Back Directory | [Name]
4-[[(6,7-Dihydro-7-oxo-8H-pyrrolo[2,3-g]benzothiazol-8-ylidene)methyl]amino]benzenesulfonamide | [CAS]
388627-21-2 | [Synonyms]
GW297361
4-[[(6,7-Dihydro-7-oxo-8H-pyrrolo[2,3-g]benzothiazol-8-ylidene)methyl]amino]benzenesulfonamide | [Molecular Formula]
C16H12N4O3S2 | [MOL File]
388627-21-2.mol | [Molecular Weight]
372.42 |
| Chemical Properties | Back Directory | [density ]
1.682±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | [form ]
Solid | [pka]
9.22±0.20(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
GW297361 is an oxindole CDK inhibitor that elicits a Pho85-selective response in cells. GW297361 inhibits yeast Cdk1 and Pho85 with IC50s of 20 nM and 400 nM in vitro, respectively[1]. | [IC 50]
yeast Cdk1: 20 nM (IC50); yeast Pho85: 400 nM (IC50); human CDK2: 1.9 nM (IC50); human CDK9: 10 nM (IC50); human CDK1: 30 nM (IC50); human CDK4: 300 nM (IC50); VEGFR2: 120 nM (IC50); SRC: 930 nM (IC50) | [References]
[1] Kung C, et al. Selective kinase inhibition by exploiting differential pathway sensitivity. Chem Biol. 2006 Apr;13(4):399-407. DOI:10.1016/j.chembiol.2006.02.004 |
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