| Chemical Properties | Back Directory | [Boiling point ]
631.2±65.0 °C(Predicted) | [density ]
1.42±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
7.26±0.10(Predicted) | [color ]
Yellow to orange |
| Hazard Information | Back Directory | [Description]
IW-927 is a potent and selective antagonist of TNFα/TNFRc1 interaction. | [Uses]
IW927 is a potent small molecule antagonist that blocks the binding of TNF-α to TNFRc1 with an IC50 value of 50 nM and disrupts TNFα-induced IκB phosphorylation with an IC50 value of 600 nM[1]. | [References]
[1] Percy H. Carter, et al. Photochemically enhanced binding of small molecules to the tumor necrosis factor receptor-1 inhibits the binding of TNF-alpha. Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):11879-84. |
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