| Identification | Back Directory | [Name]
GS 39783 | [CAS]
39069-52-8 | [Synonyms]
GS 39783
N,N'-DICYCLOPENTYL-2-(METHYLTHIO)-5-NITRO-4,6-PYRIMIDINEDIAMINE
N,N'-Dicyclopentyl-2-(methylthio)-5-nitro-4,6-pyrimidinediaamine
N4,N6-Dicyclopentyl-2-(methylthio)-5-nitropyrimidine-4,6-diamine
4,6-Pyrimidinediamine, N4,N6-dicyclopentyl-2-(methylthio)-5-nitro-
N,N'-DICYCLOPENTYL-2-METHYLSULFANYL-5-NITRO-PYRIMIDINE-4,6-DIAMINE | [Molecular Formula]
C15H23N5O2S | [MDL Number]
MFCD06201849 | [MOL File]
39069-52-8.mol | [Molecular Weight]
337.44 |
| Hazard Information | Back Directory | [Uses]
GS 39783 is an allosteric positive modulator of GABAB receptors. GS 39783 attenuates acute cocaine-induced hyperlocomotion and blocks cocaine-induced Fos induction in the striatal complex. | [Definition]
ChEBI: N4,N6-dicyclopentyl-2-(methylthio)-5-nitropyrimidine-4,6-diamine is an aryl sulfide. | [Biological Activity]
Novel positive allosteric modulator of GABA B receptor function. Potentiates the effects of GABA on [ 35 S]GTP γ S binding at recombinant and native GABA B receptors (EC 50 values are 2.1 and 3.1 μ M respectively). Decreases cocaine self-administration, blocks the rewarding properties of nicotine and produces anxiolytic-like activity without the side effects associated with baclofen or benzodiazepines. | [storage]
Store at RT |
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