| Identification | Back Directory | [Name]
O-(2-(vinyloxy)ethyl)hydroxylamine | [CAS]
391212-29-6 | [Synonyms]
O-(2-(Vinyloxy)
2-(Vinyloxy)ethoxyaMine
Selumetinib Intermediate
1-[2-(Aminooxy)ethoxy]ethylene
O-(2-ETHENOXYETHYL)HYDROXYLAMINE
O-(2-(vinyloxy)ethyl)hydroxylamine
O-[2-(ethenyloxy)ethyl]Hydroxylamine
HydroxylaMine, O-[2-(ethenyloxy)ethyl]- | [Molecular Formula]
C4H9NO2 | [MDL Number]
MFCD09951926 | [MOL File]
391212-29-6.mol | [Molecular Weight]
103.12 |
| Chemical Properties | Back Directory | [Boiling point ]
60-65 °C(Press: 20 Torr) | [density ]
0.972 | [storage temp. ]
-20°C, protect from light, stored under nitrogen | [pka]
4.07±0.70(Predicted) | [Appearance]
Colorless to light yellow Liquid | [InChI]
InChI=1S/C4H9NO2/c1-2-6-3-4-7-5/h2H,1,3-5H2 | [InChIKey]
XZTSFVPMMQNIAJ-UHFFFAOYSA-N | [SMILES]
NOCCOC=C | [CAS DataBase Reference]
391212-29-6 |
| Hazard Information | Back Directory | [Uses]
O-(2-(vinyloxy)ethyl)hydroxylamine is a pharmaceutical intermediate compound used in the preparation of the antitumour agents Selumetinib and Binimetinib. | [Synthesis]
1-[2-(Aminooxy)ethoxy]ethylene is prepared as follows:
Step A: 2-(2-(vinyloxy)ethoxy)isoindoline-1,3-dione
To a solution of 2-(vinyloxy)ethanol (20.4 mL, 227 mmol), triphenylphosphine (59.5 g, 227 mmol), and N-hydroxyphthalimide (37.0 |
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