| Identification | Back Directory | [Name]
Eleutheroside E | [CAS]
39432-56-9 | [Synonyms]
Eleutheroside
ELUTHEROSIDE E
ELEUTHEROSIDE E
Manyprickle Acathopanax Root
(-)-SYRINGARESINOL DIGLUCOSIDE
Acanthopanax senticosus (Rupr. Maxim.) Harms
Related CAS No: 19046-36-7 96038-87-8 66791-77-3
Eleutheroside E, 98%, from Acanthopanax senticosus (Rupr. & Maxim.) Harms
b-D-Glucopyranoside,[(1R,3aR,4S,6aS)-tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl]bis(2,6-diMethoxy-4,1-phenylene)bis-
[(1R,3aR,4S,6aS)-Tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl]bis(2,6-dimethoxy-4,1-phenylene) bis-β-D-glucopyranoside
β-D-Glucopyranoside, [(1R,3aR,4S,6aS)-tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl]bis(2,6-dimethoxy-4,1-phenylene) bis-
(2R,3S,4R,5R,6S)-2-[4-[4-[3,5-Dimethoxy-4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-1,3,3a,4,6,6a-hexahydrofuro[4,3-c]furan-1-yl]-2,6-dimethoxyphenoxy]-6-(hydroxymethyl)oxane-3,4,5-triol | [EINECS(EC#)]
609-679-3 | [Molecular Formula]
C34H46O18 | [MDL Number]
MFCD00210498 | [MOL File]
39432-56-9.mol | [Molecular Weight]
742.72 |
| Chemical Properties | Back Directory | [Melting point ]
269～270℃ | [Boiling point ]
935.7±65.0 °C(Predicted) | [density ]
1.474±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO (Slightly), Ethyl Acetate (Slightly), Pyridine (Slightly, Sonicated) | [form ]
Solid | [pka]
12.45±0.70(Predicted) | [color ]
White to Off-White | [Stability:]
Hygroscopic | [InChIKey]
FFDULTAFAQRACT-MDXYHMFDNA-N |
| Hazard Information | Back Directory | [Chemical Properties]
White crystalline powder, easily soluble in water, derived from Acanthopanax senticosus. | [Uses]
Eleutheroside E is used in the treatment of collagen-induced arthritis. Used in the suppression of inflammatory cytokine release. Successful in the treatment of rheumatoid arthritis. Also used in the regulation of adipogenesis | [Definition]
ChEBI: Eleutheroside E is a lignan and a glycoside. | [in vivo]
Eleutheroside E (0.003%, oral, daily, for five weeks) improves liver glucose metabolism in obese type 2 diabetes mice by upregulating glycolysis and downregulating gluconeogenesis[1].
Eleutheroside E (15-60 mg/kg, oral, once daily, three weeks) alleviates arthritis in a collagen-induced arthritis mouse model[3].
Eleutheroside E (50 mg/kg, oral, once daily, four weeks) prevents cognitive deficits caused by radiation in mice[4]. | Animal Model: | db/db mice[1] | | Dosage: | Containing 0.003% of the diet; 5 weeks | | Administration: | Oral | | Result: | Improved blood lipids, significantly reduced blood sugar and serum insulin levels, induced HOMA-IR, increased insulin sensitivity, and protected pancreatic α and β cells from diabetic damage. |
| Animal Model: | Collageninduced arthritis (CIA) mice[3] | | Dosage: | 15, 30, 60 mg/kg; daily; 3 weeks | | Administration: | Oral | | Result: | Reduced mean arthritis score and arthritis incidence, reduced inflammatory cell infiltration, mesenchymal formation, cartilage damage and bone erosion in CIA mice, and decreased TNF-α and IL-6. |
| Animal Model: | Mice irradiated with 60Co-γ rays[4] | | Dosage: | 50 mg/kg; daily; 4 weeks | | Administration: | Oral | | Result: | Improved cognitive and spatial memory impairments in irradiated mice, protected hippocampal neurons, and activated the PKA/CREB/BDNF signaling pathway. |
| [target]
NF-kB | TNF-α | IL Receptor | P450 (e.g. CYP17) | IFN-γ |
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