| Identification | Back Directory | [Name]
Akebia saponin D | [CAS]
39524-08-8 | [Synonyms]
AkebosideD
Asperosaponin Ⅵ
Akebia saponin D
Asperosaponin VI
Dipsacaceae saponin
Akebia saponin D USP/EP/BP
Asperosaponin VI (Akeboside D)
Akebia saponin D(Asperosaponin VI)
Asperosaponin VI, 98%, from Dipsacales
3'-Amino-2'-Hydroxy-1,1' biphenyl-3-cAsperosaponin VI
TIANFUCHEM--39524-08-8--High purity Akebia saponin D factory price
Hederagenin 3-O-alpha-L-arabinopyranosyl-28-beta-D-glucopyranosyl(1→6)-beta-D-glucopyranoside
Olean-12-en-28-oic acid, 3-(α-L-arabinopyranosyloxy)-23-hydroxy-, 6-O-β-D-glucopyranosyl-β-D-glucopyranosyl ester, (3β,4α)- | [Molecular Formula]
C47H76O18 | [MDL Number]
MFCD25371916 | [MOL File]
39524-08-8.mol | [Molecular Weight]
929.099 |
| Chemical Properties | Back Directory | [Melting point ]
234-235 °C | [Boiling point ]
990.2±65.0 °C(Predicted) | [density ]
1.43 | [storage temp. ]
Inert atmosphere,Store in freezer, under -20°C | [solubility ]
DMSO (Slightly, Sonicated), Methanol (Slightly, Sonicated) | [form ]
Solid | [pka]
12.50±0.70(Predicted) | [color ]
White to Pale Beige | [biological source]
(Dipsacus asper) | [optical activity]
[α]/D +13 to +18°, c =0.5 in methanol | [Water Solubility ]
H2O: 3mg/mL, clear (warmed) |
| Hazard Information | Back Directory | [Uses]
Asperosaponin VI is a steroidal extract with anti-inflammatory and antinociceptive activity. long term use has been seen to attenuate cardiac dysfunction. | [Definition]
ChEBI: Akebia saponin D is a triterpenoid saponin that is hederagenin attached to a alpha-L-arabinopyranosyl residue at position 3 via a glycosidic linkage and a 6-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl residue at position 28 via an ester linkage. It is the active ingredient found in the traditional Chinese herb Radix Dipsaci. It has a role as an apoptosis inducer, an antineoplastic agent, a plant metabolite, an anti-inflammatory agent, a bone density conservation agent, a neuroprotective agent and an antilipemic drug. It is a triterpenoid saponin, a trisaccharide derivative, a pentacyclic triterpenoid and a carboxylic ester. It is functionally related to a hederagenin. | [Biological Activity]
Akebia saponin D (ASD) is a bioactive triterpenoid saponin isolated from the rhizome of Dipsacus asper Wall th at is used as an anti-osteoporosis drug. Akebia saponin D exhibits therapeutic effects in number of disease models including cancerAlzheimerμs diseasecardiovascular diseaseand bone fractures. Akebia saponin D protects against nonalcoholic fatty liver disease (NAFLD) liver damage in mice model of NAFLD. ASD decreases hepatic steatosis and heptocyte apoptosis through autophagy modulation. Akebia saponin D prevents oleic acid induced lipid droplets accumulation and increases autophagic flux BRL cells. | [in vivo]
Asperosaponin VI (20 mg/kg; intravenous injection; 3 weeks) can accelerate wound healing and angiogenesis in a full-thickness cutaneous wound model of rats[3].
Asperosaponin VI (40 mg/kg; intraperitoneal injection; 3 weeks) has antidepressant effects in mice with chronic mild stress[4]. | Animal Model: | Male 8-week-old C57BL/6 mice treated chronic mild stress (CMS)[4] | | Dosage: | 40 mg/kg | | Administration: | Intraperitoneal injection (i.p.); 3 weeks | | Result: | Significantly improved depression-like behaviors in CMS-induced mice, as shown by increased sucrose preference, prolonged latency in the forced swimming test and feeding latency in the novelty-suppressed feeding test, and shortened immobility time in the tail suspension test and forced swimming test.
Partially reversed CMS-induced weight loss.
Induced hippocampal microglia to switch from a pro-inflammatory to a neuroprotective phenotype, and regulated the levels of pro-inflammatory and anti-inflammatory cytokines.
Exerted anti-inflammatory and antidepressant effects through PPAR-γ pathway.
Promoted microglia-neuron crosstalk and prevented CMS-induced synaptic dysfunction of hippocampal neurons.
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| [IC 50]
Caspase 3 |
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