| Identification | Back Directory | [Name]
2,4-Dichloropyrido[3,2-d]pyrimidine | [CAS]
39551-54-7 | [Synonyms]
4-dichloropyrido[3
5,6-DIMETHYLPYRAZI...
2,4-dichloropyrido[3,2-d]pyrimidine
Pyrido[3,2-d]pyrimidine, 2,4-dichloro-
2,4-Dichloropyrido[3,2-d]pyrimidine ISO 9001：2015 REACH | [Molecular Formula]
C7H3Cl2N3 | [MDL Number]
MFCD11046863 | [MOL File]
39551-54-7.mol | [Molecular Weight]
200.02 |
| Chemical Properties | Back Directory | [Melting point ]
168-169 ºC | [density ]
1.573 | [storage temp. ]
Inert atmosphere,Store in freezer, under -20°C | [pka]
-1.31±0.30(Predicted) | [Appearance]
Off-white to yellow Solid | [InChI]
InChI=1S/C7H3Cl2N3/c8-6-5-4(2-1-3-10-5)11-7(9)12-6/h1-3H | [InChIKey]
UVVFNZJVLRJSMW-UHFFFAOYSA-N | [SMILES]
C1(Cl)=NC(Cl)=C2N=CC=CC2=N1 |
| Hazard Information | Back Directory | [Synthesis]
2,4-Dichloropyrido[3,2-d]pyrimidine was synthesized using 2,4-dihydroxypyrido[3,2-d]pyrimidine as starting material in the following steps:
(2) Intermediate B3 (lg) was mixed with phosphorus oxychloride (POCl3) and phosphorus pentachloride (PCl5) and reacted by refluxing at 135°C to obtain intermediate C3 in 48% yield.
The reaction equation was as follows: | [References]
[1] Synlett, 2006, # 12, p. 1938 - 1942
[2] Patent: CN106083742, 2016, A. Location in patent: Paragraph 0185; 0188; 0189
[3] Journal of the American Chemical Society, 1956, vol. 78, p. 973,974
[4] Journal of the Chemical Society, 1956, p. 1045,1053
[5] Patent: WO2010/37765, 2010, A2. Location in patent: Page/Page column 61 |
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