| Identification | Back Directory | [Name]
BN82002 HYDROCHLORIDE SALT | [CAS]
396073-89-5 | [Synonyms]
BN 82002;BN-82002
BN82002 hydrochloride
CDC25 Phosphatase Inhibitor I
CDC25 Phosphatase Inhibitor I, BN82002
CDC25 Phosphatase Inhibitor I, BN82002 - CAS 396073-89-5 - Calbiochem
Phenol, 4-(dimethylamino)-2-methoxy-6-[[methyl[2-(4-nitrophenyl)ethyl]amino]methyl]- | [Molecular Formula]
C19H25N3O4 | [MDL Number]
MFCD08276984 | [MOL File]
396073-89-5.mol | [Molecular Weight]
359.42 |
| Chemical Properties | Back Directory | [Melting point ]
92-93 °C | [Boiling point ]
532.6±50.0 °C(Predicted) | [density ]
1.216±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C
| [solubility ]
DMSO: 10 mg/mL
| [form ]
solid
| [pka]
10.07±0.48(Predicted) | [color ]
tan
| [InChI]
1S/C19H25N3O4/c1-20(2)17-11-15(19(23)18(12-17)26-4)13-21(3)10-9-14-5-7-16(8-6-14)22(24)25/h5-8,11-12,23H,9-10,13H2,1-4H3 | [InChIKey]
GOKYHQGRIIXMNE-UHFFFAOYSA-N | [SMILES]
[N+](=O)([O-])c1ccc(cc1)CCN(Cc2c(c(cc(c2)N(C)C)OC)O)C |
| Hazard Information | Back Directory | [Uses]
BN82002 is a potent, selective and irreversible inhibitor of CDC25 phosphatase family. BN82002 inhibits CDC25A, CDC25B2, CDC25B3, CDC25C CDC25A, and 25C-cat with IC50 values of 2.4, 3.9, 6.3, 5.4, and 4.6 μM, respectively. BN82002 displays ~20-fold greater selectivity over CD45 tyrosine phosphatase[1]. | [Biological Activity]
Cell permeable: yes''Primary Target
CDC25A''Product does not compete with ATP.''Reversible: no''Target IC50: 2.43.96.35.4and 4.6 μM for CDC25 phosphatase family 25A25B225B325Cand 25C-catrespectively | [storage]
Store at -20°C | [References]
[1] Brezak MC, et al. A novel synthetic inhibitor of CDC25 phosphatases: BN82002. Cancer Res. 2004 May 1;64(9):3320-5. DOI:10.1158/0008-5472.can-03-3984 |
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| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
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