| Identification | Back Directory | [Name]
(2-MERCAPTOETHYL)-GUANIDINE SULFATE | [CAS]
3979-00-8 | [Synonyms]
MEG SULFATE
meg hemisulfate salt
XJKZAAUVINNNNC-UHFFFAOYSA-N
(2-MERCAPTOETHYL)-GUANIDINE SULFATE
1-?(2-?Mercaptoethyl)?guanidine Sulfate
mercaptoethylguanidine hemisulfate salt | [Molecular Formula]
C3H11N3O4S2 | [MDL Number]
MFCD02265423 | [MOL File]
3979-00-8.mol | [Molecular Weight]
217.267 |
| Hazard Information | Back Directory | [Uses]
MEG (sulfate) is a selective NOS2 inhibitor. MEG protects against plasma extravasation and bone destruction. | [in vivo]
MEG (10 mg/kg; i.p. for 5 d) attenuates the degree of lipid peroxidation, protein oxidation, and peroxynitrites level and ameliorated the decrease of antioxidant enzymes activities in the esophagus of rats subjected to caustic burn injury[3].
MEG (30-60 mg/kg; a single i.p.) decreases mean arterial blood pressure (MAP) of normal rats[1].
MEG (10 mg/kg; a single i.p.) improves the renal dysfunction and tissue injury induced by ischemia/reperfusion (I/R) of rat kidney[4].
| Animal Model: | Sprague-Dawley rats (200-250 g) were injured the esophagus[3] | | Dosage: | 10 mg/kg | | Administration: | I.p. for 5 days | | Result: | Reduced the stenosis index (SI) and the histopathologic damage score.
Decreased the malondialdehyde and protein carbonyl content and increased the activities of superoxide dismutase and glutathione peroxidase.
Regulated the nitrate and nitrite level. |
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BOC Sciences
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https://www.bocsci.com |
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