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400716-78-1

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400716-78-1 Structure

400716-78-1 Structure
IdentificationBack Directory
[Name]

AC-GLU-ASP(EDANS)-LYS-PRO-ILE-LEU-PHE-PHE-ARG-LEU-GLY-LYS(DABCYL)-GLU-NH2
[CAS]

400716-78-1
[Synonyms]

Cathepsin D FRET Substrate
Ac-Glu-Asp(EDANS)-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Gly-Lys(DABCYL)-Glu-NH
AC-GLU-ASP(EDANS)-LYS-PRO-ILE-LEU-PHE-PHE-ARG-LEU-GLY-LYS(DABCYL)-GLU-NH2
Ac-Glu-Asp(EDANS)-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Gly-Lys(DABCYL)-Glu-NH2 trifluoroacetate salt
L-α-Glutamine, N-acetyl-L-α-glutamyl-N-[2-[(5-sulfo-1-naphthalenyl)amino]ethyl]-L-asparaginyl-L-lysyl-L-prolyl-L-isoleucyl-L-leucyl-L-phenylalanyl-L-phenylalanyl-L-arginyl-L-leucylglycyl-N6-[4-[[4-(dimethylamino)phenyl]azo]benzoyl]-L-lysyl- (9CI)
[Molecular Formula]

C104H146N24O23S
[MDL Number]

MFCD18782546
[MOL File]

400716-78-1.mol
[Molecular Weight]

2132.48
Chemical PropertiesBack Directory
[storage temp. ]

-15°C
[Sequence]

Ac-Glu-{Asp(EDANS)}-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Gly-{Lys(DABCYL)}-Glu-NH2
Hazard InformationBack Directory
[Uses]

Ac-Glu-Asp(EDANS)-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Gly-Lys(DABCYL)-Glu-NH2 is a cathepsin D substrate, that can be used for cathepsin D FRET assay[1].
[IC 50]

Cathepsin D
[References]

[1] Eketj?ll S, et al. AZD3293: A Novel, Orally Active BACE1 Inhibitor with High Potency and Permeability and Markedly Slow Off-Rate Kinetics. J Alzheimers Dis. 2016;50(4):1109-23. DOI:10.3233/JAD-150834
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