| Identification | Back Directory | [Name]
Pyrazolo[1,5-a]pyridine-6-carbonitrile, 2-(4-fluorophenyl)-3-(4-pyridinyl)- | [CAS]
401816-26-0 | [Synonyms]
Pyrazolo[1,5-a]pyridine-6-carbonitrile, 2-(4-fluorophenyl)-3-(4-pyridinyl)- | [Molecular Formula]
C19H11FN4 | [MOL File]
401816-26-0.mol | [Molecular Weight]
314.32 |
| Hazard Information | Back Directory | [Uses]
Yck2-IN-1 (Compound 2a) is an inhibitor of the fungal Candida albicans Yck2 kinase. It exhibits an IC50 of approximately 80 nM against Yck2 and a MIC80 of 12.5 μM against C. albicans, with good metabolic stability (66% remaining in mouse liver microsomes). In a mouse model of drug-resistant candidiasis, Yck2-IN-1 significantly reduced fungal burden in the kidneys. Yck2-IN-1 holds promise for research in the field of antifungal infection[1]. | [References]
[1] Puumala E, et al. Structure-guided optimization of small molecules targeting Yck2 as a strategy to combat Candida albicans. Nat Commun. 2025 Mar 4;16(1):2156. DOI:10.1038/s41467-025-57346-z |
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