| Identification | Back Directory | [Name]
3-Oxo-14-hydroxy-5β-bufa-20,22-dienolide | [CAS]
4029-65-6 | [Synonyms]
Bufalon
Bufalone
14-Hydroxy-3-oxo-5β-bufa-20,22-dienolide
3-Oxo-14-hydroxy-5β-bufa-20,22-dienolide
Bufa-20,22-dienolide, 14-hydroxy-3-oxo-, (5β)- | [Molecular Formula]
C24H32O4 | [MOL File]
4029-65-6.mol | [Molecular Weight]
384.52 |
| Hazard Information | Back Directory | [Uses]
3-Oxo-bufalin is an active compound that can be isolated from cultured toad liver tissue. 3-Oxo-bufalin can be produced through a metabolic pathway, and it is a metabolite of Bufalin (HY-N0877) catalyzed by the stereoselective 3β-dehydrogenase. Bufalin is a Na+/K+-ATPase inhibitor and has anti-tumor activity[1]. | [References]
[1] Ruan L J, et al. 3α-Hydroxybufadienolides in Bufo gallbladders: structural insights and biotransformation[J]. Natural Products and Bioprospecting, 2024, 14(1): 19. |
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