| Identification | Back Directory | [Name]
methiozolin | [CAS]
403640-27-7 | [Synonyms]
methiozolin
Methiozolin 100 μg/mL in Acetonitrile
Isoxazole, 5-[[(2,6-difluorophenyl)methoxy]methyl]-4,5-dihydro-5-methyl-3-(3-methyl-2-thienyl)- | [Molecular Formula]
C17H17F2NO2S | [MOL File]
403640-27-7.mol | [Molecular Weight]
337.38 |
| Hazard Information | Back Directory | [Uses]
Methiozolin is commonly used in herbicidal mixtures. it is a bluegrass selective herbicide. | [Mechanism of action]
Root uptake, slow acting, strongly inhibits plant cell wall biosynthesis in susceptible grasses | [Synthesis]
A method for the preparation of high-purity methiozolin (Formula 1), the method comprising reaction of 4,5-dihydro-5-methyl-3-{(3-methylthiophene-2-yl)-isoxazole-5-yl}methanol represented by Formula 2 below with 2,6-difluorobenzyl chloride (or bromide) represented by Formula 3 below in the presence of an alkali metal salt and a phase transfer catalyst in a mixed solvent system comprising water and an organic solvent at a temperature of 50 to 100° C., followed by crystallizing a concentrate of an isolated organic layer in a mixed solvent comprising water and alcohol or a mixed solvent comprising alcohol and aliphatic hydrocarbon:
 | [Pesticide Type]
Herbicide |
|
|