| Identification | Back Directory | [Name]
3-PYRIDINAMINE, 6-(1-METHYLETHYL)- | [CAS]
405103-02-8 | [Synonyms]
6-lsopropylpyridin-3-aMine
6-Isopropylpyridin-3-amine
5-AMino-2-isopropylpyridine
3-Amino-6-isopropylpyridine
6-Isopropyl-pyridin-3-ylamine
6-(propan-2-yl)pyridin-3-aMine
5-Amino-2-isopropylpyridine 95%
6-(1-Methylethyl)-3-Pyridinamine
3-PYRIDINAMINE, 6-(1-METHYLETHYL)-
3-Pyridinamine,6-(1-methylethyl)-(9CI)
6-isopropylpyridin-3-amine hydrochloride
3-PYRIDINAMINE, 6-(1-METHYLETHYL)- ISO 9001：2015 REACH | [Molecular Formula]
C8H12N2 | [MDL Number]
MFCD08460245 | [MOL File]
405103-02-8.mol | [Molecular Weight]
136.19 |
| Chemical Properties | Back Directory | [Boiling point ]
255.1±20.0 °C(Predicted) | [density ]
1.008±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [pka]
6.77±0.10(Predicted) | [Appearance]
Light yellow to brown Liquid | [InChI]
InChI=1S/C8H12N2/c1-6(2)8-4-3-7(9)5-10-8/h3-6H,9H2,1-2H3 | [InChIKey]
XYGFISRAXLLACA-UHFFFAOYSA-N | [SMILES]
C1=NC(C(C)C)=CC=C1N |
| Hazard Information | Back Directory | [Uses]
6-Isopropylpyridin-3-amine is used to prepare quinolinonecarboxamides as modulators of ATP-binding cassette transporters. | [Synthesis]
General procedure for the synthesis of 3-amino-6-isopropylpyridine from 2-isopropyl-5-nitropyridine: 2-isopropyl-5-nitropyridine (1.30 g, 7.82 mmol) was dissolved in methanol (20 mL) and Raney Ni catalyst (0.25 g) was added. The reaction mixture was stirred for 2 hours at room temperature under hydrogen (1 atm) atmosphere. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under reduced pressure to afford 2-isopropyl-5-aminopyridine (E-9) (0.55 g, 52% yield). The product was characterized by 1H NMR (CDCl3): δ 8.05 (s, 1H), 6.93-6.99 (m, 2H), 3.47 (br s, 2H), 2.92-3.02 (m, 1H), 1.24-1.26 (m, 6H).ESI-MS showed the molecular ion peak at 137.2 m/z (MH+). | [References]
[1] Patent: US2011/98311, 2011, A1
[2] Patent: US2012/309758, 2012, A1
[3] Patent: US2015/231142, 2015, A1. Location in patent: Paragraph 0700 |
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