| Identification | Back Directory | [Name]
N-[5-(3-pyridinyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]Butanamide | [CAS]
405221-09-2 | [Synonyms]
MRT80
MRT-80
MRT 80
MRT00055778
N-[5-(3-pyridinyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]Butanamide | [Molecular Formula]
C15H15N5O | [MDL Number]
MFCD28128342 | [MOL File]
405221-09-2.mol | [Molecular Weight]
281.31 |
| Hazard Information | Back Directory | [Description]
MRT80 is a novel inhibitor of GSK-3 in vitro, de-stabilizing MDM2 and stabilizing p53 protein and E2F-1. | [Uses]
GSK-3 inhibitor 7 (compound 22) is a glycogen synthase kinase-3 (GSK-3) inhibitor. GSK-3 inhibitor 7 can be used in nervous system research[1]. | [References]
[1] Witherington J, et al. 5-aryl-pyrazolo[3,4-b]pyridines: potent inhibitors of glycogen synthase kinase-3 (GSK-3). Bioorg Med Chem Lett. 2003 May 5;13(9):1577-80. DOI:10.1016/s0960-894x(03)00134-3 |
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