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405225-21-0

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405225-21-0 Structure

405225-21-0 Structure
IdentificationBack Directory
[Name]

NFPS
[CAS]

405225-21-0
[Synonyms]

NFPS
N-[3-([1,1-Biphenyl]-4-yloxy)-3-(4-fluorophenyl)propyl]-N-methylglycine
2-[[3-(4-fluorophenyl)-3-(4-phenylphenoxy)propyl]-methylamino]acetic acid
Glycine, N-[3-([1,1'-biphenyl]-4-yloxy)-3-(4-fluorophenyl)propyl]-N-methyl-
2-((3-([1,1'-Biphenyl]-4-yloxy)-3-(4-fluorophenyl)propyl)(methyl)amino)acetic acid
[Molecular Formula]

C24H24FNO3
[MDL Number]

MFCD07772265
[MOL File]

405225-21-0.mol
[Molecular Weight]

393.45
Chemical PropertiesBack Directory
[storage temp. ]

Store at +4°C
[solubility ]

Soluble in DMSO > 10 mM
[form ]

Powder
Hazard InformationBack Directory
[Uses]

NFPS is a non-transportable inhibitor of GlyT1.
[Biological Activity]

Selective, non-transportable inhibitor of GlyT1 which displays no activity on GlyT2 or the transport of proline, GABA or glutamate (IC 50 values are 2.8, 9.8 and? 56000 nM for hGlyT1, rGlyT1 and rGlyT2 respectively). Enhances the amplitude of the NMDA component of glutamatergic EPSCs.
[IC 50]

hGlyT1: 2.8 nM (IC50); rGlyT1: 9.8 nM (IC50)
[storage]

Store at +4°C
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