| Hazard Information | Back Directory | [Description]
A 20832 is an inhibitor that Inhibits resolvase-promoted site-specific recombination postsynaptically at strand cleavage. It does not inhibit resolvase binding to res, as measured by filter binding, or synapse formation. DNase I analysis in the presence of A20832 indicates that only site I of res is bound by resolvase. | [Uses]
A20832 is a specific resolvase inhibitor that blocks both the recombination and topoisomerase activities of resolvase. A20832 inhibits the site-specific recombination reaction mediated by the Tn3-encoded resolvase protein at the strand cleavage step and has no effect on synapsis[1]. | [References]
[1] Flanagan PM, et al. Inhibitor analysis of synapsis by resolvase. J Biol Chem. 1989 Oct 5;264(28):16892-6. PMID:2550464 |
|
|