| Identification | Back Directory | [Name]
piprofurol | [CAS]
40680-87-3 | [Synonyms]
piprofurol
Piprofurolum
α-(p-Hydroxyphenethyl)-4,7-dimethoxy-6-[(2-piperidinoethyl)oxy]-5-benzofuranmethanol
4,7-Dimethoxy-α-[2-(4-hydroxyphenyl)ethyl]-6-[2-(1-piperidinyl)ethoxy]-5-benzofuranmethanol
5-Benzofuranmethanol, α-[2-(4-hydroxyphenyl)ethyl]-4,7-dimethoxy-6-[2-(1-piperidinyl)ethoxy]- | [EINECS(EC#)]
255-035-6 | [Molecular Formula]
C26H33NO6 | [MDL Number]
MFCD00868578 | [MOL File]
40680-87-3.mol | [Molecular Weight]
455.548 |
| Hazard Information | Back Directory | [Uses]
Piprofurol is a calcium channel inhibitor. Piprofurol inhibits the calcium-induced contractions in isolated potassium depolarized preparations of rat aorta in a concentration-dependent manner and relaxes the K+-induced contraction of the dog coronary artery and the rabbit basilar artery. Piprofurol exerts a negative inotropic effect on guinea-pig papillary muscle, with the EC50 of 5 μM[1]. | [References]
[1] Pourrias B, et al. Calcium blocking properties of piprofurol. Arch Int Pharmacodyn Ther. 1985;274(2):223-239. PMID:4026458 |
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