| Identification | Back Directory | [Name]
SKULLCAPFLAVONE I | [CAS]
41060-16-6 | [Synonyms]
Panicolin
Skullcapflavon I
SKULLCAPFLAVONE I
5,2'-Dihydroxy-7,8-dimethoxyflavone
2',5-Dihydroxy-7,8-dimethoxyflavone
5-hydroxy-2-(2-hydroxyphenyl)-7,8-dimethoxychromen-4-one
5-Hydroxy-2-(2-hydroxyphenyl)-7,8-dimethoxy-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one, 5-hydroxy-2-(2-hydroxyphenyl)-7,8-dimethoxy- | [Molecular Formula]
C17H14O6 | [MDL Number]
MFCD02259466 | [MOL File]
41060-16-6.mol | [Molecular Weight]
314.29 |
| Chemical Properties | Back Directory | [Melting point ]
254-256℃ | [Boiling point ]
573.6±50.0 °C(Predicted) | [density ]
1.402 | [solubility ]
Soluble in chloroform and methanol; | [form ]
powder | [pka]
6.81±0.40(Predicted) | [color ]
Yellow | [Water Solubility ]
insoluble in water | [InChI]
1S/C17H14O6/c1-21-14-8-12(20)15-11(19)7-13(23-17(15)16(14)22-2)9-5-3-4-6-10(9)18/h3-8,18,20H,1-2H3 | [InChIKey]
CZRGNFVQUYWGKP-UHFFFAOYSA-N | [SMILES]
OC1=C(C(C=C(C2=CC=CC=C2O)O3)=O)C3=C(OC)C(OC)=C1 |
| Hazard Information | Back Directory | [Uses]
Skullcapflavone I can be isolated from A. nallamalayana. Skullcapflavone I inhibits collagenase and elastase enzyme with IC50s of 106.74 μM and 186.70 μM. Skullcapflavone I has anticancer activities by down-regulating miR-23a[1]. | [target]
Caspase | NO | PGE | IL Receptor | [References]
[1] Yang B, et al. Anti-cancer, Anti-collagenase and Anti-elastase Potentials of Some Natural Derivatives: In vitro and in silico Studies. J Oleo Sci. 2023;72(5):557-570. DOI:10.5650/jos.ess22337
[2] Cui J, et al. Skullcapflavone I has a potent anti-pancreatic cancer activity by targeting miR-23a. Biofactors. 2020 Sep;46(5):821-830. DOI:10.1002/biof.1621 |
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