| Identification | Back Directory | [Name]
Coumarin 106 | [CAS]
41175-45-5 | [Synonyms]
COUMARIN 106
COUMARIN 478
11-hexahydro-
Exciton Coumarin 478
Coumarin106,lasergrade
Coumarin 106Coumarin 478
Coumarin 106,pure,laser grade
COUMARIN 106, LASER GRADE, PURE
1h,5h-cyclopenta[3,4][1]benzopyrano[6,7,8-ij]quinolizin-12(9h)-one,2,3,6,7,10,
2,3,6,7,10,11-HEXAHYDRO-1H,5H-CYCLOPENTA[3,4][1] BENZOPYRANO[6,7,8-IJ]QUINOLIZIN-12(9H)-ONE | [EINECS(EC#)]
255-246-3 | [Molecular Formula]
C18H19NO2 | [MDL Number]
MFCD00041949 | [MOL File]
41175-45-5.mol | [Molecular Weight]
281.35 |
| Chemical Properties | Back Directory | [Appearance]
yellow powder and chunks | [Melting point ]
149 °C
| [Boiling point ]
538.4±50.0 °C(Predicted) | [density ]
1.32±0.1 g/cm3(Predicted) | [form ]
powder to crystal | [pka]
6.38±0.20(Predicted) | [color ]
Light orange to Yellow to Green | [λmax]
375nm(Acetone)(lit.) | [EPA Substance Registry System]
1H,5H-Cyclopenta[ 3,4][1]benzopyrano[6,7,8- ij]quinolizin-12(9H)-one, 2,3,6,7,10,11-hexahydro-(41175-45-5) |
| Hazard Information | Back Directory | [Chemical Properties]
yellow powder and chunks | [Uses]
Coumarin 106 (Coumarin 478) is a dipolar laser dye. Coumarin 106 is an inhibitor of AChE and BChE. Coumarin 106 displays mixed-type AChE inhibition with a pIC50=4.97 and Ki=2.36 μM. Coumarin 106 inhibits BChE with slightly lower potency (pIC50=4.56)[1][2]. | [References]
[1] Patil SK, et al. Determination of ground and excited state dipole moments of dipolar laser dyes by solvatochromic shift method. Spectrochim Acta A Mol Biomol Spectrosc. 2014 Apr 5;123:117-26. DOI:10.1016/j.saa.2013.12.031
[2] Fallarero A, et al. Inhibition of acetylcholinesterase by coumarins: the case of coumarin 106. Pharmacol Res. 2008 Sep-Oct;58(3-4):215-21. DOI:10.1016/j.phrs.2008.08.001 |
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TCI AMERICA
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