| Identification | Back Directory | [Name]
Spiro[oxirane-2,3'-quinuclidine] | [CAS]
41353-91-7 | [Synonyms]
3-Methylenequinuclidine oxide
3-Methylenequinuclidine epoxide
Spiro[oxirane-2,3'-quinuclidine]
Spiro[1-azabicyclo[2.2.2]octane-3,2'-oxirane]
1'-azaspiro[oxirane-2,3'-bicyclo[2.2.2]octane]
(1'S,2R,4'S)-1'-azaspiro[oxirane-2,3'-bicyclo[2.2.2]octane] | [Molecular Formula]
C8H13NO | [MDL Number]
MFCD11655994 | [MOL File]
41353-91-7.mol | [Molecular Weight]
139.19 |
| Chemical Properties | Back Directory | [Boiling point ]
211.3±13.0 °C(Predicted) | [density ]
1.17±0.1 g/cm3(Predicted) | [form ]
solid | [pka]
10.43±0.20(Predicted) | [InChI]
1S/C8H13NO/c1-3-9-4-2-7(1)8(5-9)6-10-8/h7H,1-6H2 | [InChIKey]
TYCHQBRUARUTCL-UHFFFAOYSA-N | [SMILES]
N12CC3(C(CC2)CC1)OC3 |
| Hazard Information | Back Directory | [Description]
1'-Azaspiro[oxirane-2,3'-bicyclo[2.2.2]octane] (also known as Spiro[oxirane-2,3'-quinuclidine]) is a key intermediate in the synthesis of Mequitazine. Mequitazine is an antihistamine preparation, commonly used to treat bronchial asthma, allergic rhinitis, urticaria, and pruritus associated with dermatological conditions (eczema, dermatitis, pruritus). | [Uses]
4-Azaspiro[bicyclo[2.2.2]octane-2,2'-oxirane] is an intermediate used in the synthesis of trans-Cevimeline Hydrochloride (C283525), which is a reagent in the preparation of spiro-oxathiolane/quinuclidine sulfoxide derivative for the treatment of central nervous and cholinergic system disease or disorders. |
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BioPharmaMatrix,Inc.
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